Jubilant Biosys is hiring for Senior Research Scientist/ Team Lead (Ph.D in Organic Chemistry)
Department: DMPK
Position: Team Lead / Senior Research Scientist
Qualification: PhD (Organic Chemistry)
Location: Bangalore
Roles & Responsibilities:
- Responsible for drug metabolism and pharmacokinetic support for discovery programs.
- Support preclinical bioanalysis
- Monitor Pharmacokinetics studies and support bioanalysis
- Providing pre-clinical ADME lead optimization support to small molecule Drug Discovery
- programs (Hit Identification to Clinical Candidate Selection) including Inflammation,
- Neuroscience, Metabolic Disorders and Anti-infective Research.
- Working as a “DMPK subject matter lead” in multidisciplinary/cross functional teams of drug
- discovery projects.
- Understand the Chemical Structure – ADME relationships and design apt strategies towards
- improving Drug like Properties of the New Chemical Entities.
- Understand the broader ADME requirements of various projects
- Conduct PK and PK/PD analysis through early pre-clinical development, and collaborate in
- PK/PD and efficacy study designs
Collaborate with safety assessment group (in need basis) on study design - Design tailor made ADME protocols for various projects
- Collate the obtained results and prepare presentations for internal and external meetings
- Contribute to the design of the critical path for various projects
- Prediction of human pharmacokinetic properties from in vitro and in vivo data
- Managing PK and PK/PD analysis through early pre-clinical development, and collaborates in
- PK/PD and efficacy study design developing robust PK/PD models
- Prediction of human pharmacokinetic properties from in vitro and in vivo data in preclinical
- species.
- Collaborates with safety assessment group on study design.
- Method validations and analytical trouble shooting; Data generation, compilation, report
- preparation; Lab note book, record keeping; SOP writing
- Candidate experience:
- Ph.D with expertise in Bioanalysis using LC-MS/MS under GLP and non-GLP environment, can lead
- project as DMPK representative, quantitation of small molecule using LC-MS/MS and can perform
- metabolite identification work on High resolution mass spectrometry.
For more details visit https://bit.ly/32tTRnm
